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SNAP 5114

CAS No. 157604-55-2

SNAP 5114( SNAP5114 | SNAP-5114 | (S)-SNAP 5114 )

Catalog No. M12251 CAS No. 157604-55-2

A GABA transport inhibitor with IC50 of 5, 21, 388 and 140 uM for hGAT-3, rGAT-2, hGAT-1 and BGT-1, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SNAP 5114
  • Note
    Research use only, not for human use.
  • Brief Description
    A GABA transport inhibitor with IC50 of 5, 21, 388 and 140 uM for hGAT-3, rGAT-2, hGAT-1 and BGT-1, respectively.
  • Description
    A GABA transport inhibitor with IC50 of 5, 21, 388 and 140 uM for hGAT-3, rGAT-2, hGAT-1 and BGT-1, respectively; increases thalamic GABA levels and is an anticonvulsant following systemic administration in vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SNAP5114 | SNAP-5114 | (S)-SNAP 5114
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    GAT
  • Recptor
    GAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    157604-55-2
  • Formula Weight
    505.61
  • Molecular Formula
    C30H35NO6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (197.78 mM)
  • SMILES
    O=C([C@@H]1CN(CCOC(C2=CC=C(OC)C=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)CCC1)O
  • Chemical Name
    1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-(S)-3-piperidinecarboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dhar TG, et al. J Med Chem. 1994 Jul 22;37(15):2334-42. 2. Christiansen B, et al. J Biol Chem. 2007 Jul 6;282(27):19331-41. 3. Doengi M, et al. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17570-5. 4. Dvorzhak A, et al. J Physiol. 2010 Jul 1;588(Pt 13):2351-60.
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